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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 7 Documents

Search results for , issue "Vol 18 No 3, 2007" : 7 Documents clear

Profile of sulphacetamide pharmacokinetics on uranyl nitrate-induced renal failure rats Djoko Wahyono; Arief Rahman Hakim; Agung Endro Nugroho
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Kidney is a vital organ which has main function to maintain the body homeostasis. The role of kidney is the excretion (elimination) of waste product, and if there is pathologically a renal failure so will change the drug pharmacokinetics and in turn change it’s potency. The present study evaluated the effect of uranyl nitrate-induced renal failure on the pharmacokinetics profiles of sulphacetamide in rats.The study was conducted by employing a completely randomized design in male Wistar in bred rat (aged 2-2.5 months, 150-250 g). The animals in group I were given sulphacetamide sodium with an oral single dose 100.0 mg/kg BW (control group) and in group II were given pretreatment with uranyl nitrate at 3 days before sulphacetamide administration.After collected at some certain times, the drug concentrations on bloods were analyzed by an ultraviolet spectrophometer. The results have shown that uranyl nitrate-induced renal failure decreased the primer pharmacokinetics parameter i.e. total clearance (ClT) and volume of distribution in steady state (Vdss), significantly (P<0.05). The decreasing of these parameter could cause alteration of the secondary pharmacokinetics parameters of sulphacetamide and these derivates i.e. Cmax, tmax, AUC0-240, AUC0-inf, MRT, K and t1/2 elimination significantly (P<0.05). According from the results, it is concluded that uranyl nitrate-induced renal failure affected the pharmacokinetics of sulphacetamide or could increase the sulphacetamide concentration in blood.Key words : sulphacetamide, pharmacokinetics, renal failure, uranyl nitrate

Influence of mechanical and thermal energy on rifampicin Sundani N. Soewandhi; Kosasih .; Rachmat Mauludin; Irvan Khaeruddin
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The same raw material has opportunity to show different physical properties if it is produced by different industries. For such reason, rifampicin was chosen as a raw materials model, thats obtaining from five resource countries and were obtained from five different suppliers, each coded A, B, C, D and E. Each raw material was handled under tribomechanic and thermal treatment. Mechanical treatment was carried out by using grinding mill at 100 rpm for 30 minutes. Thermal treatment was carried out by oven at 105oC for 2 hours. Transformation occured, was identified by differential scanning calorymetry (DSC), X-ray powder diffraction and dissolution rate. The intrinsic dissolution rate was determined in 900 mL HCl 0,1N oxygen free, using basket and calculated through simultaneously determination method using uv spectrophotometry at λabs.maks. 475 nm. Thermograms of five milled raw material showed endothermic curve at 58oC without obviously melting curve.Thermogram of heated raw material did not show endothermic curve except its melting at 188oC-192oC. Crystallinity indices of the raw materials decreased from C, E, B, A to D. The milled raw materials were mixture of rifampicin II (2%) and amorphous (98%). A and D were mixture of rifampicin form II and fines (amorph). The other samples were only rifampicin form II. All of the raw materials showed different dissolution rates. Rifampicin B,C and D had sameness dissolution rate, whether milled or heated.Key words: Rifampicin II, rifampicin amorphous, DSC, powder X-ray diffraction, dissolution rate

Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent Hadisoewignyo, Lannie; Fudholi, Achmad
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.

Chemopreventive effect of ethanolic extract of Gynura procumbens (Lour), Merr on the carcinogenesis of Rat breast cancer development Meiyanto, Edy; Susilowati, Sri; Tasminatun, Sri; Murwanti, Retno; ., Sugiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Gynura procumbens (Lour) Merr., empirically, used to prevent cancer development and has been proven to be able to suppress lung cancer development. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBA-induced breast cancer development. Sprague Dawly Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 3 levels of doses, namely 250, 500, and 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, 500, and 750 mg/kgBW reduced tumor incidence by 60%, 30 %, and 20 % respectively. The doses of 500 and 750 mg/kgBW exhibited strong suppression of tumor multiplicity, where as the dose of 250 performed less potential suppression. In conclusion, ethanolic extract of G. procumbens performs chemopreventive effect to suppress breast cancer development at the dose of 250 mg/kgBW.Key words : chemopreventive, Gynura procumbens (Lour) Merr, breast cancer.

Phenolic content and antibacterial properties of various extracts of gambir (Uncaria gambir Roxb) Rindit Pambayun; Murdijati Gardjito; Slamet Sudarmadji; Kapti Rahayu Kuswanto
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Extraction of gambir product with various solvents gave vary in amount of yields, phenolic contents, and its antibacterial properties. Extraction was performed by maseration and Soxhlet methods with some solvents; chloroform, ethyl acetate, ethanol, water, and their combination. The results showed that the highest yield of extract obtained from the solvent combination of ethanol and water (1:1 v/v) both at the maseration and Soxhlet metods, i.e. 84.77 and 87.69 %, respectivelly. Soxhlet method gave the yield of extract higher than that of maseration method. The highest phenolic content was found at the extracts using ethyl acetate both in maseration and soxlet methods, i.e. 88,30 and 90,85 %, respectivelly. Antobacterial properties on the Gram-positive bacteria such as Streptococcus mutans, Staphylococcus aureus, and Bacillus subtilis, indicated that the extracts extracted by using ethyl acetate gave highest inhibitory properties. On the other hand, the extracts did not inhibit Gram-negative bacteria. Extraction was continued by using solvent combination of ethanol and water at the various proportion and at the three levels of temperature, 4, 30, and 60 °C. The results showed that solvent combination of ethanol and water (1:2), gave the highest yield of extracts but lower in phenolic contents and aantibacterial properties.Key words: antibacterial, phenolic content, extract of Uncaria gambir Roxb

Application of quantum chemical descriptors in QSAR analysis of curcumin derivatives as ethoxyresorufin o-dealkylation inhibitor Sudarmanto, B.S. Ari; Oetari, R. A.
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Quantitative Structure-Activity Relationship (QSAR) have established 26 curcumin derivatives to correlate and predict ethoxyresorufin Odeethylation (EROD) inhibitory activity. The AM1 semiempirical quantum mechanic method was applied in geometry optimization and descriptor calculation. Genetic Algoritm combined with Multiple Linear Regression Analysis (GA-MLRA) technique was applied to select the descriptors and to generate the equation that relate the structural features to the biological activity. The result of GA-MLRA showed that quantum chemical descriptors QSAR had good statistical fits. Energy level of the lowest unoccupied molecular orbital, logP, momen dipole, and nett charge of C1, C6 and C9 atoms play an important role in EROD inhibition.Key words : QSAR, quantum-chemical descriptor, curcumin derivatives, EROD.

Antioxidant–free radical scavenging of flavonoid from The Leaves of Stelechocarpus burahol (Bl.) Hook f. & Th. Sunarni, Titik; Pramono, Suwidjiyo; Asmah, Ratna
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The activity testing of flavonoid compounds as antioxidant and as scavenger of free radical, isolated from the Stelechocarpus burahol leaves had been performed. The aqueous extract of the leaves was concentrated and then suspended in ethanol to produce ethanolic fraction. The fraction was chromatographed on several paper chromatography systems to produce isolate with chromatographic purity.The all isolated flavonoid was identified by paper chromatography system. Especially, the B4b isolate were identified further using spectrometer UV-Vis, FT-IR and ¹H-NMR. Their antioxidant activities were done by the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method.The all isolated flavonoid showed activity as DPPH scavenger. Among these isolate, B4b exhibited a strong free radical scavenging with an EC50 value of 6.43 μg/mL. They were identified and B4b isolate was pressumed as flavon with hydroxyl group on C-3, C-7, C-3', C-4' and methyl on C-5.Key words : Stelechocarpus burahol, flavonoid, antioxidant, DPPH

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